Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

A functioning gene drive system could fundamentally change our strategies for the control of vector-borne diseases by facilitating rapid dissemination of transgenes that prevent pathogen transmission or reduce vector capacity. CRISPR/Cas9 gene drive promises such a mechanism, which works by converti...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Champer, Jackson, Reeves, Riona, Oh, Suh Yeon, Liu, Chen, Liu, Jingxian, Clark, Andrew G., Messer, Philipp W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518997/
https://ncbi.nlm.nih.gov/pubmed/28727785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006796
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