Reducing resistance allele formation in CRISPR gene drive

CRISPR homing gene drives can convert heterozygous cells with one copy of the drive allele into homozygotes, thereby enabling super-Mendelian inheritance. Such a mechanism could be used, for example, to rapidly disseminate a genetic payload in a population, promising effective strategies for the con...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Champer, Jackson, Liu, Jingxian, Oh, Suh Yeon, Reeves, Riona, Luthra, Anisha, Oakes, Nathan, Clark, Andrew G., Messer, Philipp W.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003519/
https://ncbi.nlm.nih.gov/pubmed/29735716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720354115
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