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A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population
Engineered gene drives are being explored as a new strategy in the fight against vector-borne diseases due to their potential for rapidly spreading genetic modifications through a population. However, CRISPR-based homing gene drives proposed for this purpose have faced a major obstacle in the format...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7533649/ https://ncbi.nlm.nih.gov/pubmed/32929034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004373117 |
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