A toxin-antidote CRISPR gene drive system for regional population modification

Engineered gene drives based on a homing mechanism could rapidly spread genetic alterations through a population. However, such drives face a major obstacle in the form of resistance against the drive. In addition, they are expected to be highly invasive. Here, we introduce the Toxin-Antidote Recess...

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Udgivet i:Nat Commun
Main Authors: Champer, Jackson, Lee, Esther, Yang, Emily, Liu, Chen, Clark, Andrew G., Messer, Philipp W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046741/
https://ncbi.nlm.nih.gov/pubmed/32109227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14960-3
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