A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population

Engineered gene drives are being explored as a new strategy in the fight against vector-borne diseases due to their potential for rapidly spreading genetic modifications through a population. However, CRISPR-based homing gene drives proposed for this purpose have faced a major obstacle in the format...

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Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Champer, Jackson, Yang, Emily, Lee, Esther, Liu, Jingxian, Clark, Andrew G., Messer, Philipp W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2020
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533649/
https://ncbi.nlm.nih.gov/pubmed/32929034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004373117
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