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Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

Point mutations in the p53 gene are the most frequently identified genetic change in human cancer. They convert murine p53 from a tumour suppressor gene into a dominant transforming oncogene able to immortalize primary cells and bring about full transformation in combination with an activated ras ge...

詳細記述

保存先:
書誌詳細
主要な著者: Gannon, J V, Greaves, R, Iggo, R, Lane, D P
フォーマット: Artigo
言語:Inglês
出版事項: 1990
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC551855/
https://ncbi.nlm.nih.gov/pubmed/1691710
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