2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR). Male C57BL/6 mice orally gavaged with TCDD (0.01–30 µg/kg) every 4 days for 28 days exhibited bile duct proliferation and peric...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fader, Kelly A., Nault, Rance, Zhang, Chen, Kumagai, Kazuyoshi, Harkema, Jack R., Zacharewski, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517430/
https://ncbi.nlm.nih.gov/pubmed/28725001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05656-8
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