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Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9

Elevated level of blood phosphate (Pi) associated with chronic kidney disease (CKD) is a risk factor of aortic valve calcification. Aortic valve interstitial cells (AVICs) display osteogenic responses to high Pi although the underlying mechanism is incompletely understood. Sox9 is a pro-chondrogenic...

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Bibliografiske detaljer
Udgivet i:J Mol Med (Berl)
Main Authors: Li, Fei, Yao, Qingzhou, Ao, Lihua, Cleveland, Joseph C., Dong, Nianguo, Fullerton, David A., Meng, Xianzhong
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516801/
https://ncbi.nlm.nih.gov/pubmed/28332126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-017-1527-3
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