Altered MicroRNA Expression Is Responsible for the Pro‐Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves

BACKGROUND: The transition of aortic valve interstitial cells (AVICs) to myofibroblastic and osteoblast‐like phenotypes plays a critical role in calcific aortic valve disease progression. Several microRNAs (miRs) are implicated in stem cell differentiation into osteoblast. We hypothesized that an ep...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Song, Rui, Fullerton, David A., Ao, Lihua, Zhao, Ke‐seng, Reece, T. Brett, Cleveland, Joseph C., Meng, Xianzhong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533027/
https://ncbi.nlm.nih.gov/pubmed/28438736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.005364
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