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BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells
Biglycan accumulates in aortic valves affected by calcific aortic valve disease (CAVD), and soluble biglycan up-regulates BMP-2 expression in human aortic valve interstitial cells (AVICs) via Toll-like receptor (TLR) 2 and induces AVIC pro-osteogenic reprogramming, characterized by elevated pro-oste...
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| Publicado no: | J Mol Med (Berl) |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4369167/ https://ncbi.nlm.nih.gov/pubmed/25412776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-014-1229-z |
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