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BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells

Biglycan accumulates in aortic valves affected by calcific aortic valve disease (CAVD), and soluble biglycan up-regulates BMP-2 expression in human aortic valve interstitial cells (AVICs) via Toll-like receptor (TLR) 2 and induces AVIC pro-osteogenic reprogramming, characterized by elevated pro-oste...

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Bibliografiske detaljer
Udgivet i:J Mol Med (Berl)
Main Authors: Song, Rui, Fullerton, David A., Ao, Lihua, Zheng, Daniel, Zhao, Ke-seng, Meng, Xianzhong
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369167/
https://ncbi.nlm.nih.gov/pubmed/25412776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-014-1229-z
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