ADAMTS5 deficiency in calcified aortic valves is associated with elevated pro-osteogenic activity in valvular interstitial cells

OBJECTIVE: Extracellular matrix (ECM) proteinases are implicated in the pathogenesis of calcific aortic valve disease (CAVD). The ADAMTS5 (A Disintegrin and Metalloproteinase with Thrombospondin motifs 5) enzyme is secreted, matrix-associated metalloendopeptidase, capable of degrading ECM proteins,...

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Publicado en:Arterioscler Thromb Vasc Biol
Main Authors: Li, Fei, Song, Rui, Ao, Lihua, Reece, T. Brett, Cleveland, Joseph C., Dong, Nianguo, Fullerton, David A., Meng, Xianzhong
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516888/
https://ncbi.nlm.nih.gov/pubmed/28546218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309021
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