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ADAMTS5 deficiency in calcified aortic valves is associated with elevated pro-osteogenic activity in valvular interstitial cells
OBJECTIVE: Extracellular matrix (ECM) proteinases are implicated in the pathogenesis of calcific aortic valve disease (CAVD). The ADAMTS5 (A Disintegrin and Metalloproteinase with Thrombospondin motifs 5) enzyme is secreted, matrix-associated metalloendopeptidase, capable of degrading ECM proteins,...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5516888/ https://ncbi.nlm.nih.gov/pubmed/28546218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309021 |
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