Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice

Calcific aortic valve disease is a chronic inflammatory process, and aortic valve interstitial cells (AVICs) from diseased aortic valves express greater levels of osteogenic factors in response to proinflammatory stimulation. Here, we report that lower cellular levels of IL-37 in AVICs of diseased h...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zeng, Qingchun, Song, Rui, Fullerton, David A., Ao, Lihua, Zhai, Yufeng, Li, Suzhao, Ballak, Dov B., Cleveland, Joseph C., Reece, T. Brett, McKinsey, Timothy A., Xu, Dingli, Dinarello, Charles A., Meng, Xianzhong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321035/
https://ncbi.nlm.nih.gov/pubmed/28137840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619667114
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