Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice

Calcific aortic valve disease is a chronic inflammatory process, and aortic valve interstitial cells (AVICs) from diseased aortic valves express greater levels of osteogenic factors in response to proinflammatory stimulation. Here, we report that lower cellular levels of IL-37 in AVICs of diseased h...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Zeng, Qingchun, Song, Rui, Fullerton, David A., Ao, Lihua, Zhai, Yufeng, Li, Suzhao, Ballak, Dov B., Cleveland, Joseph C., Reece, T. Brett, McKinsey, Timothy A., Xu, Dingli, Dinarello, Charles A., Meng, Xianzhong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321035/
https://ncbi.nlm.nih.gov/pubmed/28137840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619667114
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