Massively parallel sequencing analysis of synchronous fibroepithelial lesions supports the concept of progression from fibroadenoma to phyllodes tumor

Phyllodes tumors (PTs) and fibroadenomas (FAs) are fibroepithelial lesions (FELs) of the breast. Although mutations affecting exon 2 of MED12 are highly recurrent in FAs and PTs, TERT promoter hotspot mutations are frequently found in PTs but are vanishingly rare in FAs. Malignant transformation of...

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Veröffentlicht in:NPJ Breast Cancer
Hauptverfasser: Piscuoglio, Salvatore, Geyer, Felipe C, Burke, Kathleen A, Murray, Melissa P, Ng, Charlotte KY, Mota, Alba, Marchio, Caterina, Berman, Samuel H, Norton, Larry, Brogi, Edi, Weigelt, Britta, Reis-Filho, Jorge S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515337/
https://ncbi.nlm.nih.gov/pubmed/28721388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjbcancer.2016.35
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