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Methylator-induced, Mismatch Repair-dependent G(2) Arrest Is Activated through Chk1 and Chk2
S(N)1 DNA methylating agents such as the nitrosourea N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) elicit a G(2)/M checkpoint response via a mismatch repair (MMR) system-dependent mechanism; however, the exact nature of the mechanism governing MNNG-induced G(2)/M arrest and how MMR mechanistically par...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC551512/ https://ncbi.nlm.nih.gov/pubmed/15647386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-02-0089 |
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