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Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1
The mismatch repair (MMR) gene hMLH1 is mutated in ∼50% of hereditary non-polyposis colon cancers and transcriptionally silenced in ∼25% of sporadic tumours of the right colon. Cells lacking hMLH1 display microsatellite instability and resistance to killing by methylating agents. In an attempt to st...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2003
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC156088/ https://ncbi.nlm.nih.gov/pubmed/12727890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg216 |
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