Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1

The mismatch repair (MMR) gene hMLH1 is mutated in ∼50% of hereditary non-polyposis colon cancers and transcriptionally silenced in ∼25% of sporadic tumours of the right colon. Cells lacking hMLH1 display microsatellite instability and resistance to killing by methylating agents. In an attempt to st...

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Main Authors: Cejka, Petr, Stojic, Lovorka, Mojas, Nina, Russell, Anna Marie, Heinimann, Karl, Cannavó, Elda, di Pietro, Massimiliano, Marra, Giancarlo, Jiricny, Josef
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2003
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC156088/
https://ncbi.nlm.nih.gov/pubmed/12727890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg216
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