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Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA

O(6)-Methylguanine ((Me)G) is a highly cytotoxic DNA modification generated by S(N)1-type methylating agents. Despite numerous studies implicating DNA replication, mismatch repair (MMR), and homologous recombination (HR) in (Me)G toxicity, its mode of action has remained elusive. We studied the mole...

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Bibliografiske detaljer
Main Authors: Mojas, Nina, Lopes, Massimo, Jiricny, Josef
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2113034/
https://ncbi.nlm.nih.gov/pubmed/18079180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.455407
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