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Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination
During class switch recombination (CSR), antigen-stimulated B-cells rearrange their immunoglobulin constant heavy chain (C(H)) loci to generate antibodies with different effector functions. CSR is initiated by activation-induced deaminase (AID), which converts cytosines in switch (S) regions, repeti...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824095/ https://ncbi.nlm.nih.gov/pubmed/26743004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1535 |
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