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Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1
Mutations in the mismatch repair (MMR) genes MSH2, MSH6, MLH1 and PMS2 are associated with Lynch Syndrome (LS), a familial predisposition to early-onset cancer of the colon and other organs. Because not all LS families carry mutations in these four genes, the search for cancer-associated mutations w...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4066805/ https://ncbi.nlm.nih.gov/pubmed/24829445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku419 |
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