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The mismatch repair system modulates curcumin sensitivity through induction of DNA strand breaks and activation of G2/M checkpoint

The highly conserved mismatch (MMR) repair system corrects post-replicative errors and modulates cellular responses to genotoxic agents. Here, we show that the MMR system strongly influences cellular sensitivity to curcumin. Compared to MMR-proficient cells, isogenically-matched MMR-deficient cells...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jiang, Zhihua, Jin, ShunQian, Yalowich, Jack C., Brown, Kevin D., Baskaran, R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837109/
https://ncbi.nlm.nih.gov/pubmed/20145018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0627
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