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The mismatch repair system modulates curcumin sensitivity through induction of DNA strand breaks and activation of G2/M checkpoint
The highly conserved mismatch (MMR) repair system corrects post-replicative errors and modulates cellular responses to genotoxic agents. Here, we show that the MMR system strongly influences cellular sensitivity to curcumin. Compared to MMR-proficient cells, isogenically-matched MMR-deficient cells...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2837109/ https://ncbi.nlm.nih.gov/pubmed/20145018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0627 |
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