Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth

ICP0 is a multi-functional herpes simplex virus type 1 (HSV-1) immediate-early (IE) gene product that contributes to efficient virus growth and reactivation from latency. Here we show that HSV-1-induced cell-cycle arrest at the G2/M border requires ICP0 and Chk2 kinase and that ICP0 expression by tr...

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Main Authors: Li, Han, Baskaran, Rajasekaran, Krisky, David M., Bein, Kiflai, Grandi, Paola, Cohen, Justus B., Glorioso, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706573/
https://ncbi.nlm.nih.gov/pubmed/18321553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.01.038
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