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Muscarinic receptor regulates extracellular signal regulated kinase by two modes of arrestin binding
Binding of agonists to G-protein–coupled receptors (GPCRs) activates heterotrimeric G proteins and downstream signaling. Agonist-bound GPCRs are then phosphorylated by protein kinases and bound by arrestin to trigger desensitization and endocytosis. Arrestin plays another important signaling functio...
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| Publicat a: | Proc Natl Acad Sci U S A |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5514713/ https://ncbi.nlm.nih.gov/pubmed/28652372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700331114 |
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