Muscarinic receptor regulates extracellular signal regulated kinase by two modes of arrestin binding

Binding of agonists to G-protein–coupled receptors (GPCRs) activates heterotrimeric G proteins and downstream signaling. Agonist-bound GPCRs are then phosphorylated by protein kinases and bound by arrestin to trigger desensitization and endocytosis. Arrestin plays another important signaling functio...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Jung, Seung-Ryoung, Kushmerick, Christopher, Seo, Jong Bae, Koh, Duk-Su, Hille, Bertil
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514713/
https://ncbi.nlm.nih.gov/pubmed/28652372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700331114
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