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Local alignment of ligand binding sites in proteins for polypharmacology and drug repositioning

The administration of drugs is a key strategy in pharmacotherapy to treat diseases. Drugs are typically developed to modulate the function of specific proteins, which are directly associated with particular disease states. Nonetheless, recent studies suggest that protein-drug interactions are rather...

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Vydáno v:Methods Mol Biol
Hlavní autor: Brylinski, Michal
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513668/
https://ncbi.nlm.nih.gov/pubmed/28451975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-7015-5_9
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