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A threading-based method (FINDSITE) for ligand-binding site prediction and functional annotation

The detection of ligand-binding sites is often the starting point for protein function identification and drug discovery. Because of inaccuracies in predicted protein structures, extant binding pocket-detection methods are limited to experimentally solved structures. Here, FINDSITE, a method for lig...

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Bibliographic Details
Main Authors: Brylinski, Michal, Skolnick, Jeffrey
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224172/
https://ncbi.nlm.nih.gov/pubmed/18165317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707684105
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