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Very CIN-ful: Whole Chromosome Instability Promotes Tumor Suppressor Loss of Heterozygosity
Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of...
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| Gepubliceerd in: | Cancer Cell |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5513159/ https://ncbi.nlm.nih.gov/pubmed/19962661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.11.014 |
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