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Very CIN-ful: Whole Chromosome Instability Promotes Tumor Suppressor Loss of Heterozygosity

Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of...

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Bibliographic Details
Published in:Cancer Cell
Main Authors: Sotillo, Rocio, Schvartzman, Juan-Manuel, Benezra, Robert
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513159/
https://ncbi.nlm.nih.gov/pubmed/19962661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.11.014
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