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Mad2 is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition
Multiple mechanisms have been proposed to explain how Rb and p53 tumor suppressor loss lead to chromosome instability (CIN). It was recently shown that Rb pathway inhibition causes overexpression of the mitotic checkpoint gene Mad2 but whether Mad2 overexpression is required to generate CIN in this...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3120099/ https://ncbi.nlm.nih.gov/pubmed/21665145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.04.017 |
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