Φορτώνει......
Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer’s disease
Accumulation of amyloid-β (Aβ) peptide in the brain is the first critical step in the pathogenesis of Alzheimer’s disease (AD). Studies in humans suggest that Aβ clearance from the brain is frequently impaired in late-onset AD. Aβ accumulation leads to the formation of Aβ aggregates which injure syn...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Sci Transl Med |
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| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5512541/ https://ncbi.nlm.nih.gov/pubmed/27030596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad3650 |
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