The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands

HLA-B(∗)46:01 was formed by an intergenic mini-conversion, between HLA-B(∗)15:01 and HLA-C(∗)01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into H...

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Pubblicato in:Cell Rep
Autori principali: Hilton, Hugo G., McMurtrey, Curtis P., Han, Alex S., Djaoud, Zakia, Guethlein, Lisbeth A., Blokhuis, Jeroen H., Pugh, Jason L., Goyos, Ana, Horowitz, Amir, Buchli, Rico, Jackson, Ken W., Bardet, Wilfred, Bushnell, David A., Robinson, Philip J., Mendoza, Juan L., Birnbaum, Michael E., Nielsen, Morten, Garcia, K. Christopher, Hildebrand, William H., Parham, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Author(s). 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510751/
https://ncbi.nlm.nih.gov/pubmed/28514659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.04.059
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