The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands

HLA-B(∗)46:01 was formed by an intergenic mini-conversion, between HLA-B(∗)15:01 and HLA-C(∗)01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into H...

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Publicado en:Cell Rep
Main Authors: Hilton, Hugo G., McMurtrey, Curtis P., Han, Alex S., Djaoud, Zakia, Guethlein, Lisbeth A., Blokhuis, Jeroen H., Pugh, Jason L., Goyos, Ana, Horowitz, Amir, Buchli, Rico, Jackson, Ken W., Bardet, Wilfred, Bushnell, David A., Robinson, Philip J., Mendoza, Juan L., Birnbaum, Michael E., Nielsen, Morten, Garcia, K. Christopher, Hildebrand, William H., Parham, Peter
Formato: Artigo
Idioma:Inglês
Publicado: The Author(s). 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510751/
https://ncbi.nlm.nih.gov/pubmed/28514659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.04.059
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