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Quantitative High-Throughput Screening Using a Coincidence Reporter Biocircuit

Reporter-biased artifacts, compounds that interact directly with the reporter enzyme used in a high-throughput screening (HTS) assay, and not the biology or pharmacology being interrogated, are now widely recognized to reduce the efficiency and quality of HTS used for chemical probe and therapeutic...

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Bibliografiske detaljer
Udgivet i:Curr Protoc Neurosci
Main Authors: Schuck, Brittany W., MacArthur, Ryan, Inglese, James
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510169/
https://ncbi.nlm.nih.gov/pubmed/28398644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpns.27
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