A Quantitative High-Throughput Screen for Modulators of IL-6 Signaling: A Model for Interrogating Biological Networks using Chemical Libraries

Small molecule modulators are critical for dissecting and understanding signaling pathways at the molecular level. Interleukin 6 (IL-6) is a cytokine that signals via the JAK/STAT pathway and is implicated in cancer and inflammation. To identify modulators of this pathway, we screened a chemical col...

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Bibliografiske detaljer
Main Authors: Johnson, Ronald L., Huang, Ruili, Jadhav, Ajit, Southall, Noel, Wichterman, Jennifer, MacArthur, Ryan, Xia, Menghang, Bi, Kun, Printen, John, Austin, Christopher P., Inglese, James
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747079/
https://ncbi.nlm.nih.gov/pubmed/19668870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b902021g
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