Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats

OBJECTIVE: We evaluated the therapeutic effectiveness of a new, orally active epoxyeicosatrienoic acid analog (EET-A) in rats with angiotensin II (ANG II)-dependent malignant hypertension. METHODS: Malignant hypertension was induced in Cyp1a1-Ren-2 transgenic rats by activation of the renin gene usi...

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Publicat a:J Hypertens
Autors principals: Jíchová, Šárka, Kopkan, Libor, Husková, Zuzana, Doleželová, Šárka, Neckář, Jan, Kujal, Petr, Vernerová, Zdenka, Kramer, Herbert J., Sadowski, Janusz, Kompanowska-Jezierska, Elzbieta, Reddy, Rami N., Falck, John R., Imig, John D., Červenka, Luděk
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510029/
https://ncbi.nlm.nih.gov/pubmed/27428043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0000000000001029
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