Different mechanisms of acute versus long term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats

Recent studies have shown that long-term antihypertensive action of soluble epoxide hydrolase inhibition (sEHi) in angiotensin II (ANG II)-dependent hypertension might be mediated by the suppression of intrarenal ANG II levels. To test this hypothesis, we examined the effects of acute (2 days) and c...

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Published in:Clin Exp Pharmacol Physiol
Main Authors: Sporková, Alexandra, Jíchová, Šárka, Husková, Zuzana, Kopkan, Libor, Nishiyama, Akira, Hwang, Sung Hee, Hammock, Bruce D., Imig, John D., Kompanowska-Jezierska, Elzbieta, Sadowski, Janusz, Kramer, Herbert J., Červenka, Luděk
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347520/
https://ncbi.nlm.nih.gov/pubmed/25224811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1440-1681.12310
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