20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats

We hypothesized that vascular actions of 20-hydroxyeicosatetraenoic acid (20-HETE), the product of cytochrome P450 (CYP450)-dependent ω-hydroxylase, potentiate prohypertensive actions of angiotensin II (ANG II) in Cyp1a1-Ren-2 transgenic rats, a model of ANG II-dependent malignant hypertension. Ther...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Sedláková, Lenka, Kikerlová, Soňa, Husková, Zuzana, Červenková, Lenka, Chábová, Věra Čertíková, Zicha, Josef, Falck, John R., Imig, John D., Kompanowska-Jezierska, Elzbieta, Sadowski, Janusz, Krátký, Vojtěch, Červenka, Luděk, Kopkan, Libor
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131326/
https://ncbi.nlm.nih.gov/pubmed/30054426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20171496
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