Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats

Epoxyeicosatrienoic acids (EETs) and their analogs have been identified as potent antihypertensive compounds with cardio- and renoprotective actions. Here, we examined the effect of EET-A, an orally active EET analog, and c-AUCB, an inhibitor of the EETs degrading enzyme soluble epoxide hydrolase, o...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Hrdlička, Jaroslav, Neckář, Jan, Papoušek, František, Husková, Zuzana, Kikerlová, Soňa, Vaňourková, Zdenka, Vernerová, Zdenka, Akat, Firat, Vašinová, Jana, Hammock, Bruce D., Hwang, Sung Hee, Imig, John D., Falck, John R., Červenka, Luděk, Kolář, František
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406051/
https://ncbi.nlm.nih.gov/pubmed/30881303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00159
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