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Nerve growth factor potentiates the neurotoxicity of beta amyloid.

The role of growth factors in the pathogenesis of Alzheimer disease is unknown. The beta-amyloid protein accumulates abnormally in the brain in Alzheimer disease and is neurotoxic to differentiated hippocampal neurons in culture. Nerve growth factor (NGF) increased the neurotoxic potency of a beta-a...

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Autori principali: Yankner, B A, Caceres, A, Duffy, L K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1990
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC55092/
https://ncbi.nlm.nih.gov/pubmed/2174172
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