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Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

The cellular mechanism underlying the generation of beta-amyloid in Alzheimer disease and its relationship to the normal metabolism of the amyloid precursor protein are unknown. In this report, we show that 3- and 4-kDa peptides derived from amyloid precursor protein are normally secreted. Epitope m...

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Detalhes bibliográficos
Main Authors: Busciglio, J, Gabuzda, D H, Matsudaira, P, Yankner, B A
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC46027/
https://ncbi.nlm.nih.gov/pubmed/8446635
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