Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

The identity of the RNA binding proteins (RBPs) that govern cancer stem cell remains poorly characterized. The MSI2 RBP is a central regulator of translation of cancer stem cell programs. Through proteomics analysis of the MSI2 interacting RBP network and functional shRNA screening, we identified 24...

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Publicado no:Nat Genet
Main Authors: Vu, Ly P., Prieto, Camila, Amin, Elianna M., Chhangawala, Sagar, Krivtsov, Andrei, Calvo-Vidal, M. Nieves, Chou, Timothy, Chow, Arthur, Minuesa, Gerard, Park, Sun Mi, Barlowe, Trevor S., Taggart, James, Tivnan, Patrick, Deering, Raquel P., Chu, Lisa P, Kwon, Jeong-Ah, Meydan, Cem, Perales-Paton, Javier, Arshi, Arora, Gönen, Mithat, Famulare, Christopher, Patel, Minal, Paietta, Elisabeth, Tallman, Martin S., Lu, Yuheng, Glass, Jacob, Garret-Bakelman, Francine, Melnick, Ari, Levine, Ross, Al-Shahrour, Fatima, Järås, Marcus, Hacohen, Nir, Hwang, Alexia, Garippa, Ralph, Lengner, Christopher J., Armstrong, Scott A, Cerchietti, Leandro, Cowley, Glenn S, Root, David, Doench, John, Leslie, Christina, Ebert, Benjamin L, Kharas, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508533/
https://ncbi.nlm.nih.gov/pubmed/28436985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3854
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