Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

The identity of the RNA binding proteins (RBPs) that govern cancer stem cell remains poorly characterized. The MSI2 RBP is a central regulator of translation of cancer stem cell programs. Through proteomics analysis of the MSI2 interacting RBP network and functional shRNA screening, we identified 24...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Genet
Prif Awduron: Vu, Ly P., Prieto, Camila, Amin, Elianna M., Chhangawala, Sagar, Krivtsov, Andrei, Calvo-Vidal, M. Nieves, Chou, Timothy, Chow, Arthur, Minuesa, Gerard, Park, Sun Mi, Barlowe, Trevor S., Taggart, James, Tivnan, Patrick, Deering, Raquel P., Chu, Lisa P, Kwon, Jeong-Ah, Meydan, Cem, Perales-Paton, Javier, Arshi, Arora, Gönen, Mithat, Famulare, Christopher, Patel, Minal, Paietta, Elisabeth, Tallman, Martin S., Lu, Yuheng, Glass, Jacob, Garret-Bakelman, Francine, Melnick, Ari, Levine, Ross, Al-Shahrour, Fatima, Järås, Marcus, Hacohen, Nir, Hwang, Alexia, Garippa, Ralph, Lengner, Christopher J., Armstrong, Scott A, Cerchietti, Leandro, Cowley, Glenn S, Root, David, Doench, John, Leslie, Christina, Ebert, Benjamin L, Kharas, Michael G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508533/
https://ncbi.nlm.nih.gov/pubmed/28436985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3854
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