Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs

Hematopoietic stem cells (HSCs) are maintained through the regulation of symmetric and asymmetric cell division. We report that conditional ablation of the RNA-binding protein Msi2 results in a failure of HSC maintenance and engraftment caused by a loss of quiescence and increased commitment divisio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Park, Sun-Mi, Deering, Raquel P., Lu, Yuheng, Tivnan, Patrick, Lianoglou, Steve, Al-Shahrour, Fatima, Ebert, Benjamin L., Hacohen, Nir, Leslie, Christina, Daley, George Q., Lengner, Christopher J., Kharas, Michael G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892968/
https://ncbi.nlm.nih.gov/pubmed/24395885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130736
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