Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory program

Leukemia stem cells (LSCs) are found in most aggressive myeloid diseases and contribute to therapeutic resistance. Leukemia cells exhibit a dysregulated developmental program as the result of genetic and epigenetic alterations. Overexpression of the RNA-binding protein Musashi2 (MSI2) has been previ...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Park, Sun-Mi, Gönen, Mithat, Vu, Ly, Minuesa, Gerard, Tivnan, Patrick, Barlowe, Trevor S., Taggart, James, Lu, Yuheng, Deering, Raquel P., Hacohen, Nir, Figueroa, Maria E., Paietta, Elisabeth, Fernandez, Hugo F., Tallman, Martin S., Melnick, Ari, Levine, Ross, Leslie, Christina, Lengner, Christopher J., Kharas, Michael G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362230/
https://ncbi.nlm.nih.gov/pubmed/25664853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78440
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