Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory program

Leukemia stem cells (LSCs) are found in most aggressive myeloid diseases and contribute to therapeutic resistance. Leukemia cells exhibit a dysregulated developmental program as the result of genetic and epigenetic alterations. Overexpression of the RNA-binding protein Musashi2 (MSI2) has been previ...

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Foilsithe in:J Clin Invest
Main Authors: Park, Sun-Mi, Gönen, Mithat, Vu, Ly, Minuesa, Gerard, Tivnan, Patrick, Barlowe, Trevor S., Taggart, James, Lu, Yuheng, Deering, Raquel P., Hacohen, Nir, Figueroa, Maria E., Paietta, Elisabeth, Fernandez, Hugo F., Tallman, Martin S., Melnick, Ari, Levine, Ross, Leslie, Christina, Lengner, Christopher J., Kharas, Michael G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362230/
https://ncbi.nlm.nih.gov/pubmed/25664853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78440
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