Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory program

Leukemia stem cells (LSCs) are found in most aggressive myeloid diseases and contribute to therapeutic resistance. Leukemia cells exhibit a dysregulated developmental program as the result of genetic and epigenetic alterations. Overexpression of the RNA-binding protein Musashi2 (MSI2) has been previ...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Park, Sun-Mi, Gönen, Mithat, Vu, Ly, Minuesa, Gerard, Tivnan, Patrick, Barlowe, Trevor S., Taggart, James, Lu, Yuheng, Deering, Raquel P., Hacohen, Nir, Figueroa, Maria E., Paietta, Elisabeth, Fernandez, Hugo F., Tallman, Martin S., Melnick, Ari, Levine, Ross, Leslie, Christina, Lengner, Christopher J., Kharas, Michael G.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362230/
https://ncbi.nlm.nih.gov/pubmed/25664853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78440
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