Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation

Psoriasis is a frequent and often severe inflammatory skin disease, characterized by altered epidermal homeostasis. Since we found previously that Akt/mTOR signaling is hyperactivated in psoriatic skin, we aimed at elucidating the role of aberrant mTORC1 signaling in this disease. We found that unde...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Buerger, Claudia, Shirsath, Nitesh, Lang, Victoria, Berard, Alina, Diehl, Sandra, Kaufmann, Roland, Boehncke, Wolf-Henning, Wolf, Peter
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507280/
https://ncbi.nlm.nih.gov/pubmed/28700632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180853
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items