In vitro and in vivo fitness costs associated with Mycobacterium tuberculosis RpoB mutation H526D

AIM: There is controversy regarding the potential fitness costs of rifampicin (RIF) resistance-conferring mutations in the Mycobacterium tuberculosis (Mtb) rpoB gene. We characterized the pathogenicity of an Mtb RpoB H526D mutant. MATERIALS & METHODS: A mutant containing the RpoB H526D mutation...

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Vydáno v:Future Microbiol
Hlavní autoři: Rifat, Dalin, Campodónico, Victoria L, Tao, Jing, Miller, James A, Alp, Alpaslan, Yao, Yufeng, Karakousis, Petros C
Médium: Artigo
Jazyk:Inglês
Vydáno: Future Medicine Ltd 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506874/
https://ncbi.nlm.nih.gov/pubmed/28343421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fmb-2017-0022
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