Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis

Multidrug-resistant tuberculosis (TB), defined as TB resistant to the two first-line drugs, isoniazid and rifampin, is a serious challenge to global TB eradication efforts. Although mutations in rpoA or rpoC have been proposed to compensate for this fitness cost due to rpoB mutation in rifampicin-re...

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Main Authors: Zhihong Xu, Aiping Zhou, Jiawei Wu, Aiwu Zhou, Jun Li, Shulin Zhang, Wenjuan Wu, Petros C. Karakousis, Yu-Feng Yao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-11-01
Colecção:Frontiers in Microbiology
Assuntos:
Mycobacterium tuberculosis
rifampicin resistance
fitness cost
rpoC mutation
RNA sequence
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmicb.2018.02895/full
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