The PPARγ‐SETD8 axis constitutes an epigenetic, p53‐independent checkpoint on p21‐mediated cellular senescence

Cellular senescence is a permanent proliferative arrest triggered by genome instability or aberrant growth stresses, acting as a protective or even tumor‐suppressive mechanism. While several key aspects of gene regulation have been known to program this cessation of cell growth, the involvement of t...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Shih, Chieh‐Tien, Chang, Yi‐Feng, Chen, Yi‐Tung, Ma, Chung‐Pei, Chen, Hui‐Wen, Yang, Chang‐Ching, Lu, Juu‐Chin, Tsai, Yau‐Sheng, Chen, Hua‐Chien, Tan, Bertrand Chin‐Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506440/
https://ncbi.nlm.nih.gov/pubmed/28514051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12607
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