SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

Histone modifications establish the chromatin states that coordinate the DNA damage response. In this study, we show that SETD2, the enzyme that trimethylates histone H3 lysine 36 (H3K36me3), is required for ATM activation upon DNA double-strand breaks (DSBs). Moreover, we find that SETD2 is necessa...

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Detalhes bibliográficos
Main Authors: Carvalho, Sílvia, Vítor, Alexandra C, Sridhara, Sreerama C, Martins, Filipa B, Raposo, Ana C, Desterro, Joana MP, Ferreira, João, de Almeida, Sérgio F
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038841/
https://ncbi.nlm.nih.gov/pubmed/24843002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02482
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