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Inducible knockdown of pregnancy‐associated plasma protein‐A gene expression in adult female mice extends life span

Pregnancy‐associated plasma protein‐A (PAPP‐A) knockout (KO) mice, generated through homologous recombination in embryonic stem cells, have a significantly increased lifespan compared to wild‐type littermates. However, it is unknown whether this longevity advantage would pertain to PAPP‐A gene delet...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Bale, Laurie K., West, Sally A., Conover, Cheryl A.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506424/
https://ncbi.nlm.nih.gov/pubmed/28600811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12624
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